Effect of amphetamine on corrected-QT interval change during methadone maintenance treatment in Taiwan: A prospective cohort study
| Autor: | Ye-Hsu Lu, Michael Gossop, Chieh-Liang Huang, Ni-Chi Lin, Tsang-Yaw Lin, Hsiu-Yi Wang, Chung-Ying Chen, Lin-Mei Chen, Vincent Chin-Hung Chen |
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| Rok vydání: | 2013 |
| Předmět: |
Pediatrics
medicine.medical_specialty Methadone maintenance Health (social science) business.industry Corrected qt Medicine (miscellaneous) QT interval Anesthesia medicine Medical history cardiovascular diseases Substance use Amphetamine business Prospective cohort study circulatory and respiratory physiology medicine.drug Methadone |
| Zdroj: | Drug and Alcohol Review. 33:194-201 |
| ISSN: | 0959-5236 |
| Popis: | Introduction and Aims Previous studies have suggested that methadone is associated with prolonged corrected-QT (QTc) interval, but published prospective research studies in this area are relatively scarce. This study investigates QTc interval change among methadone maintenance patients and possible associated risk factors. One of the aims is to explore the effect of amphetamines. Design and Methods This prospective cohort study with six-month follow up assesses the effect of methadone on QTc interval among a sample (n = 170) of heroin users in a methadone maintenance treatment program in Taiwan. Demographic data, substance use history, medical history and laboratory studies were collected at study enrollment. Twelve-lead electrocardiograms were performed for all participants both at study enrollment and six months later. Results The median daily methadone dose was 41 mg. A mean increase of QTc interval (17.1 ms, SD = 50.0, P |
| Databáze: | OpenAIRE |
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