Scabronines B, C, D, E and F, novel diterpenoids showing stimulating activity of nerve growth factor-synthesis, from the mushroom Sarcodon scabrosus

Autor:	Yoshiteru Oshima, Tomihisa Ohta, K. Aizawa, Takahiro Inakuma, T. Hirano, Takako Kita, Yoshiaki Takaya
Rok vydání:	1998
Předmět:	Sarcodon scabrosus Mushroom Chemical transformation chemistry.chemical_compound Nerve growth factor chemistry Stereochemistry Organic Chemistry Drug Discovery Erinacine Spectral data Chirality (chemistry) Biochemistry
Zdroj:	Tetrahedron. 54:11877-11886
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(98)83045-7
Popis:	Novel cyathane-type diterpenoids, scabronines B – F (1 – 5) were isolated from the mushroom Sarcodon scabrosus . Their structures were determined by interpretation of their spectral data and chemical transformation. The absolute stereochemistry of scabronine C (2) was confirmed by the exciton chirality method, and the chemical transformation of scabronines B, C and D (1, 2 and 3) clarified their absolute structures. The absolute stereochemistries of scabronines E and F (4 and 5) were determined by comparison of their CD spectra with that of erinacine A (7). Among these compounds, scabronines B, C and E (1, 2 and 4) exhibit stimulating activity of the synthesis of a nerve growth factor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88937608f319616fa3b77cb1fb4fb210 https://doi.org/10.1016/s0040-4020(98)83045-7 Zobrazit plný text záznamu Full Text from ScienceDirect