Formation of secondary metabolism enzymes in the tylosin producerStreptomyces T59-235

Autor:	Norbert Madry, Hermann Pape
Rok vydání:	1982
Předmět:	chemistry.chemical_classification biology General Medicine Tylosin biology.organism_classification Phosphate Biochemistry Microbiology Streptomyces chemistry.chemical_compound Enzyme chemistry Biosynthesis Genetics Transferase Secondary metabolism Molecular Biology DNA
Zdroj:	Archives of Microbiology. 131:170-173
ISSN:	1432-072X 0302-8933
DOI:	10.1007/bf01054001
Popis:	Production of the macrolide antibiotic tylosin byStreptomyces T59-235 was inhibited in cultures containing high phosphate concentrations (30 mM Pi). Vegetative growth (dry weight increase, DNA and RNA synthesis) was hardly affected. Tylosin production began when macromolecule synthesis had slowed down to minimum level; in cultures with 30 mM Pi the onset of antibiotic production was retarded compared to cultures with low phosphate concentration (5 mM). The activities of three enzyme systems involved in tylosin biosynthesis (dTDP-D-glucose-4,6-dehydratase; dTDP-mycarose-forming enzyme system; SAM: macrocin-O-methyl transferase) were measured and found to be significantly lower in cultures with 30 mM Pi than in low phosphate cultures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88936cc79b0c2ab6e429ff524b8a57dd https://doi.org/10.1007/bf01054001 Zobrazit plný text záznamu Full text from SpringerLink