Helicobacter pylori infection in childhood: Results of management with ranitidine bismuth citrate plus amoxicillin and tinidazole
| Autor: | Karim M. Farztdinov, Rinat S. H. Khasanov, Valery A. Katayev, Valery U. Sataev, Shamil M. Khusnutdinov, Eduard D. Akhunov, Alexander A. Nijevitch, Nasghat S. Kazykhanov |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Hepatology biology business.industry Anti-ulcer Agent Gastroenterology Amoxicillin Helicobacter pylori biology.organism_classification medicine.disease Tinidazole Ranitidine Duodenitis Internal medicine medicine Gastritis medicine.symptom business Antibacterial agent medicine.drug |
| Zdroj: | Journal of Gastroenterology and Hepatology. 15:1243-1250 |
| ISSN: | 0815-9319 |
| DOI: | 10.1046/j.1440-1746.2000.2326.x |
| Popis: | BACKGROUND AND AIMS: To verify whether a triple therapy bismuth citrate plus amoxicillin and tinidazole eradicates H. pylori infection in pediatric patients. METHODS: Fifty children (30 females; mean age 12.4 +/- 1.1 years, range 10-15 years) suffering from upper abdominal complaints and Helicobacter pylori (H. pylori)-associated gastroduodenal disease were treated with a 4 week course of ranitidine bismuth citrate (400 mg, twice daily) plus oral tinidazole (20 mg/kg) and amoxicillin (50 mg/kg) for the first 2 weeks. RESULTS: The endoscopic diagnoses were: esophagitis (seven cases), gastritis (six cases), gastroduodenitis (43 cases), duodenitis (one case), gastric ulcer (two cases) and duodenal ulcer (13 cases). Helicobacter pylori was eradicated in 40 (80%) patients and clinical improvement was noticed in 39 (78%) of symptomatic subjects. Duodenal ulcers were healed in all the children, but lymphoid nodular hyperplasia was persistent in all patients, independent of the H. pylori status. The potentially drug-related adverse events (blackening of the tongue, six patients; diarrhea, one patient; disturbance of taste, two patients) were registered in seven (14%) patients and dark stools were observed in 48 (96%) patients. No children withdrew from the study because of either side-effects or clinical laboratory changes. No patient had toxic levels of blood bismuth (values ranged between 2.1 and 5.4 microg/L, mean value 3.4 +/- 1.04 microg/L). CONCLUSIONS: Findings suggest that the present treatment regimen is effective enough in the resolution of H. pylori-associated peptic ulcer disease of childhood. |
| Databáze: | OpenAIRE |
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