The Role of Pyruvate Kinase M2 in Cancer Metabolism

Autor:	Matthew G. Vander Heiden, Vivian M. Liu
Rok vydání:	2015
Předmět:	Pyruvate decarboxylation Pyruvate dehydrogenase kinase General Neuroscience Cyclin-dependent kinase 2 PKM2 Biology Pyruvate dehydrogenase phosphatase Pathology and Forensic Medicine Cell biology MAP2K7 Biochemistry biology.protein ASK1 Neurology (clinical) Pyruvate kinase
Zdroj:	Brain Pathology. 25:781-783
ISSN:	1015-6305
DOI:	10.1111/bpa.12311
Popis:	The M2 isoform of pyruvate kinase is expressed preferentially in cancer cells over other pyruvate kinase isoforms. PKM2 is unique in its ability to be regulated allosterically by nutrients and growth signaling pathways, allowing cells to adapt their metabolic program to match physiological needs in different environments. Here, we discuss the role of pyruvate kinase M2 in glioma and in cancer metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::888b5553b3a33ef80cf3937e45fdb766 https://doi.org/10.1111/bpa.12311 Zobrazit plný text záznamu