Quantitative Assessment of Clinical Disease Status in Primary Sjögren's Syndrome
| Autor: | A. Wiik, Gunnar Bendixen, Karsten Asmussen, Vagn Andersen, J.J. Thorn, Klaus Bendtzen, Peter Oxholm, J. U. Prause |
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| Rok vydání: | 1997 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Systemic disease biology business.industry Cross-sectional study Vascular disease Eye disease Immunology General Medicine Disease medicine.disease Gastroenterology Rheumatology Internal medicine Immunopathology biology.protein Immunology and Allergy Medicine Antibody business |
| Zdroj: | Scandinavian Journal of Rheumatology. 26:197-205 |
| ISSN: | 1502-7732 0300-9742 |
| Popis: | Quantitative and qualitative assessment of the clinical disease manifestations in 41 primary Sjogren's syndrome (pSS) patients was performed according to a new classification model. Frequencies of subgrouped disease manifestations were as follows: 1) surface exocrine disease: 100%, 2) internal organ exocrine disease: 63%, 3) monoclonal B lymphocyte disease: 5%, 4) inflammatory vascular disease: 71%, 5) non-inflammatory vascular disease: 59%, 6) mediator induced disease: 98%. Summary scores for severity of surface exocrine disease correlated to the summary scores of all other disease manifestations (p = 0.02), to the summary scores of internal organ exocrine disease (p = 0.003), and to the summary scores of mediator induced disease (p = 0.03). Blood leucocyte counts showed significant negative correlations to levels of plasma IgG, serum IgA-RF, IgM-RF, anti-SSA/SSB antibodies, IL-6, and IL-lRa. We conclude that the model made detailed analysis of the clinical presentation of pSS possible, and thus may assi... |
| Databáze: | OpenAIRE |
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