Cetyl Trimethyl Ammonium Bromide-coated Nickel Ferrite Nanoparticles for Magnetic Hyperthermia and T2 Contrast Agents in Magnetic Resonance Imaging
| Autor: | Da-Ae Lee, Ilsu Rhee, Hongsub Bae |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010302 applied physics
Ammonium bromide Materials science Aqueous solution Induction heating General Physics and Astronomy Infrared spectroscopy Nanoparticle 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences chemistry.chemical_compound Magnetic hyperthermia chemistry Transmission electron microscopy 0103 physical sciences 0210 nano-technology Superparamagnetism Nuclear chemistry |
| Zdroj: | Journal of the Korean Physical Society. 73:1334-1339 |
| ISSN: | 1976-8524 0374-4884 |
| DOI: | 10.3938/jkps.73.1334 |
| Popis: | Spherical nickel ferrite nanoparticles were synthesized using the thermal decomposition method and coated with cetyl trimethyl ammonium bromide (CTAB) after the synthesis. Transmission electron microscopy images showed that the average diameter of the particles was 9.40 nm. The status of the CTAB-coating on the surface of the particles was checked using Fourier-transform infrared spectroscopy. Their hysteresis curve showed that the particles exhibited a superparamagnetic behavior. The T1 and the T2 relaxations of the nuclear spins were observed in aqueous solutions of the particles with different particles concentrations by using a magnetic resonance imaging (MRI) scanner, which showed that the T1 and the T2 relaxivities of the particles in water were 0.57 mM −1·s −1 and 10.42 mM −1·s −1, respectively. In addition, using an induction heating system, we evaluated their potentials for magnetic hyperthermia applications. The aqueous solution of the particles with a moderate concentration (smaller than 6.5 mg/mL) showed a saturation temperature larger than the hyperthermia target temperature of 42 °C. These findings show that the CTAB-coated nickel ferrite particles are suitable for applications as T2 contrast agents in MRI and heat generators in magnetic hyperthermia. |
| Databáze: | OpenAIRE |
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