Plasma Concentrations Of Endocannabinoids And Congeners In a Primary Care Sample Of Depressed Patients: Influence Of Biological Variables, Severity And Antidepressant Medication
| Autor: | F.J. Pavón-Morón, F. Rivas-Guerrero, Fermin Mayoral-Cleries, R. De la Torre-Fornell, P. Araos-Gómez, A. Pastor-Bosch, Raquel Nogueira-Arjona, M. Pedraz-Fernández, F. Rodríguez de Fonseca, A. Serrano-Criado, Pablo Romero-Sanchiz |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Primary care Bioinformatics Control subjects medicine.disease Endocannabinoid system 03 medical and health sciences Psychiatry and Mental health Antidepressant medication 030104 developmental biology Mood disorders Plasma concentration medicine Psychology Body mass index Depression (differential diagnoses) Clinical psychology |
| Zdroj: | European Psychiatry. 33:S422-S423 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2016.01.1524 |
| Popis: | IntroductionEndocannabinoid system has been highlighted as one of the most relevant research topics by neurobiologists, pharmacists, basic scientists and clinicians. The association between endocannabinoids and its congeners and mood disorders is relatively recent. However, evidence from both clinical and preclinical studies is increasing and many researchers point out endocannabinoid system and particularly endocannabinoids and congeners as promising pharmacological targets.Aims and objectivesThe main objective of this study is to compare the plasma concentrations of endocannabinoids and congeners between a sample of patients with depression and a sample of control subjects, and the influence of variables such as age, body mass index, gender, severity of symptoms, and antidepressant medication.MethodPlasma concentrations of endocannabinoids and congeners will be analyzed in 69 patients with depression from primary care and 47 controls using mass spectrometry analysis.ResultsStatistically significant differences in 2-arachidonoylglycerol and monoacylglycerols were found between both samples. Somatic symptoms of depression seems to be more related to these compounds that to cognitive-affective symptoms. In addition, differences between mildly and moderately depressed patients were found in concentrations of AEA, LEA, DGLEA and POEA. Patients with antidepressant medication showed higher levels of 2-AG, DGLEA and OEA.ConclusionsThe results of this study provide evidence supporting the hypothesis that in depression there is a dysregulation of the inflammatory signaling and, consequently the immune system. The results of this study could also support the realization of translational research to better understand the mechanisms of this widely distributed system.Disclosure of interestThe authors have not supplied their declaration of competing interest. |
| Databáze: | OpenAIRE |
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