Content of Peripheral Blood T- and B-Cell Subpopulations in Transgenic A53T Mice of Different Age (A Model of Parkinson’s Disease)
| Autor: | G. V. Idova, M. M. Gevorgyan, S. Ya. Zhanaeva, Maria A. Tikhonova, E. L. Al'perina |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
biology Chemistry CD3 Transgene Mutant Wild type General Medicine Phenotype Molecular biology General Biochemistry Genetics and Molecular Biology CD19 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure biology.protein medicine IL-2 receptor 030217 neurology & neurosurgery B cell |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:401-404 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We analyzed the behavior and peripheral blood T- and B-cell subpopulations in mice overexpressing the mutant form of human α-synuclein (A53T) in comparison with mice of the wild type (WT) parent C57BL/6J strain. Behavioral phenotype and the content of various cell subpopulations of A53T mice depended on animal age. Young (2-month-old mice) were characterized by low emotionality and the most pronounced changes in cell subpopulation composition (an increase in CD3+T cells and CD4+T helper cells, a decrease in CD19+B cells along with unchanged content of CD3+CD4+CD25+T-regulatory cells and CD19+CD25+B-regulatory cells). In old A53T mice (10-month-old), movement impairments appeared and increased numbers of CD4+T helper cells and CD3+CD4+CD25+T-regulatory cells were revealed. |
| Databáze: | OpenAIRE |
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