Boron trifluoride–methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity
| Autor: | Alexandr Misharev, Mar Puyol, Sergey Miltsov, Vladimir Karavan, Julián Alonso-Chamarro |
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| Rok vydání: | 2016 |
| Předmět: |
Steric effects
010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry Acetylation Reagent Drug Discovery Organic chemistry Methanol Selectivity Boron Acetanilide Boron trifluoride |
| Zdroj: | Tetrahedron Letters. 57:641-644 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2015.12.087 |
| Popis: | A boron trifluoride–methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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