Synthesis of a New Class of N-Linked Lewis and LacNAc Analogues as Potential Inhibitors of Human Fucosyltransferases: A General Method for the Incorporation of an Iminocyclitol as a Transition-State Mimetic of the Donor Sugar to the Acceptor

Autor:	Richard Martin, Ralf Wischnat, Chi-Huey Wong
Rok vydání:	1998
Předmět:	Fucosyltransferases chemistry.chemical_compound General method chemistry Transition (genetics) Reaction sequence Stereochemistry Glucosamine Organic Chemistry Sugar Acceptor Derivative (chemistry)
Zdroj:	The Journal of Organic Chemistry. 63:8361-8365
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo981245l
Popis:	A short and effective synthesis of N-linked di- and trisaccharides is described. In a high-yielding reaction sequence, the glucosamine derivative 1 was transformed to the 3-azido-2,3-dideoxy sugar ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::887292f3618f2a59915c35b4eddd2db2 https://doi.org/10.1021/jo981245l Zobrazit plný text záznamu