Recurrent Erlotinib-Induced Interstitial Lung Disease on Non-Small Cell Lung Cancer
| Autor: | Areum Kim, Sang Don Park, Seung Min Kwak, Chun Ho Shin, Lucia Kim, Hae Sung Nam, Jin Seok Park, Jae Wha Cho, Jeong Sun Ryu |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Oral chemotherapy business.industry Therapeutic effect Interstitial lung disease respiratory system medicine.disease behavioral disciplines and activities respiratory tract diseases Internal medicine medicine heterocyclic compounds In patient Erlotinib Non small cell Lung cancer business neoplasms medicine.drug |
| Zdroj: | Tuberculosis and Respiratory Diseases. 67:445 |
| ISSN: | 1738-3536 |
| DOI: | 10.4046/trd.2009.67.5.445 |
| Popis: | 1, Ⓡ ) has been considered to be a new, promising oral chemotherapy agent for local advanced or metastatic non-small cell lung cancer (NSCLC). Erlotinib is regarded as relatively safe, but interstitial lung disease (ILD) related to erlotinib has been reported on an infrequent basis in Asia. We report an histologically confirmed case of recurrent erlotinib-induced ILD. Although, the patient was highly responsive to the first erlotinib treatment, the therapy was discontinued due to erlotinib-induced ILD. After intravenous high dose methylpredinisolone treatment, ILD was improved rapidly by radiologic studies, but the particular lung cancer re-emerged. We restarted the patient erlotinib on low-dose oral methylpredinisolone, resulting in a recurrence of erlotinib-induced ILD. Our case suggests that re-administration of erlotinib should be performed on a limited basis in patients that have developed ILD on previous use, even if a therapeutic effect can be estimated. |
| Databáze: | OpenAIRE |
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