The production and cure of metahypophyseal diabetes in the cat: a biochemical and electron-microscopical study with particular reference to the changes in the islets of Langerhans of the pancreas
| Autor: | Frank George Young, M. K. Jeacock, J. D. Lever |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.medical_specialty
Glycogen Endoplasmic reticulum Pancreatic islets General Engineering Biology medicine.disease chemistry.chemical_compound Tolbutamide medicine.anatomical_structure Endocrinology chemistry Anterior pituitary Cytoplasm Diabetes mellitus Internal medicine medicine General Earth and Planetary Sciences Pancreas General Environmental Science medicine.drug |
| Zdroj: | Proceedings of the Royal Society of London. Series B. Biological Sciences. 154:139-150 |
| ISSN: | 2053-9193 0080-4649 |
| DOI: | 10.1098/rspb.1961.0025 |
| Popis: | The induction of metahypophyseal diabetes in the cat by treatment with ox anterior pituitary extract, or purified ox pituitary growth hormone, and its cure by treatment with the anti-diabetic sulphonamide, tolbutamide, is described. The fine structure and histochemistry of the pancreatic islets were investigated during the course of the diabetes and after recovery from it, by the examination of biopsy specimens. During the induction of the diabetes theβcells were denuded of their specific secretory granules and became progressively disorganized and dilated by the presence of intracellular glycogen. In those animals which had recovered from diabetes theβcells of the pancreatic islets contained a nucleus, mitochondria, Golgi membranes, and a normal complement of secretory granules and endoplasmic reticulum. In animals which did not recover from diabetes theβcells of the pancreatic islets had been destroyed. Recovery from diabetes is associated with a substantial increase in the number of cytoplasmic ribonucleic acid particles in theβcells, and also by a great expansion in the surface area of the endoplasmic reticulum. The secretory granules reappear in the Golgi region in the recoveredβcells. |
| Databáze: | OpenAIRE |
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