Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome
| Autor: | Amanda C. Chan, Jérôme Devaux, Einar Wilder-Smith, Anna Hiu Yi Wong, Takashi Kurihara, Takayuki Inoue, Nobuhiro Yuki, Masafumi Yokai |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physiology Immunoglobulin G 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Immune system Physiology (medical) medicine biology Guillain-Barre syndrome business.industry Hyporeflexia medicine.disease 3. Good health 030104 developmental biology Nociception Anesthesia Immunology Neuropathic pain biology.protein Thermal pain Neurology (clinical) medicine.symptom Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Muscle & Nerve. 57:320-324 |
| ISSN: | 0148-639X |
| DOI: | 10.1002/mus.25738 |
| Popis: | Introduction We present a painful small-fiber neuropathy variant of Guillain-Barre syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. Discussion Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain-Barre syndrome. Muscle Nerve 57: 320-324, 2018. |
| Databáze: | OpenAIRE |
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