The impact of tranilast on restenosis after coronary angioplasty: The second tranilast restenosis following angioplasty trial (TREAT-2)

Autor: Katsuo Kanmatsuse, Tadanori Aizawa, Hideo Nishikawa, Takahiko Suzuki, Kazuo Haze, Osamu Katoh, Kazuzo Katoh, Shin Suzuki, Shinichi Takase, Hirokazu Hayakawa, Shigemoto Nakanishi, Hideo Tamai, Tetsu Yamaguchi
Rok vydání: 2002
Předmět:
Zdroj: American Heart Journal. 143:506-513
ISSN: 0002-8703
DOI: 10.1067/mhj.2002.120770
Popis: Background The Tranilast Restenosis Following Angioplasty Trial showed that oral administration of 600 mg/day of tranilast for 3 months markedly reduced the restenosis rate after percutaneous transluminal coronary angioplasty (PTCA) for de novo lesions. Methods We conducted the second multicenter, randomized, double-blinded placebo-controlled trial. A total of 297 patients with 329 lesions were randomly assigned to treatment with tranilast or a placebo for 3 months after successful PTCA for both de novo and restenotic lesions. Angiographic follow-up examination was done at 3 months, and angiograms were interpreted with a quantitative approach. Results Two hundred thirty-nine lesions (72.6%) in 216 of the patients (72.7%) met the criteria and were included in the assessment of restenosis. Lesion restenosis was defined as a loss of 50% or more of the initial gain, and the restenosis rates were 18.8% in the tranilast group (n = 112) and 44.1% in the placebo group (n = 127; P =.00005). The restenosis rate, defined as a percent stenosis of ≥50% at follow-up examination, was also significantly lower in the tranilast group (25.9% versus 41.9%; P =.012). The numbers of restenotic lesions were 38 (33.9% of 112) in the tranilast group and 30 (23.6% of 127) in the placebo group. In restenotic lesions, the lesion restenosis rate was significantly lower in the tranilast subgroup (18.4% versus 53.3% with the first restenosis criterion; P =.004). Conclusion The oral administration of tranilast for 3 months markedly reduced the restenosis rate after PTCA, even in restenotic lesions. (Am Heart J 2002;143:506-13.)
Databáze: OpenAIRE
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