Apical periodontitis induces changes on oxidative stress parameters and increases Na+/K+-ATPase activity in adult rats

Autor: Karine Roversi, Camilla dos Santos Tibúrcio-Machado, Raquel Cristine Silva Barcelos, Paula Tassoni Inchaki, H.Z. Rosa, Carlos Alexandre Souza Bier, Marilise Escobar Burger
Rok vydání: 2020
Předmět:
Zdroj: Archives of Oral Biology. 118:104849
ISSN: 0003-9969
DOI: 10.1016/j.archoralbio.2020.104849
Popis: Objectives Endodontic infection can cause systemic alterations. The involvement of oxidative stress (OS) and transmembrane enzymes compose the pathogenesis of various systemic diseases. However, the relation among apical periodontitis (AP), OS parameters, and Na+/K+-ATPase (NKA) pump was not reported in the literature. This study evaluated the AP influence on OS parameters and NKA activity in adult rats. Methods Adult male Wistar rats (sixteen weeks old) were randomly assigned to two experimental groups: control (CT group; n = 8) and AP (AP group; n = 9), which was induced in the first right mandibular molar tooth. After 21 days of AP induction, mandibles were dissected for radiographic analysis. In addition, the heart, liver, pancreas, and kidney were collected for analysis of endogenous OS parameters and NKA activity. Data were analyzed by Student’s T-test. Values of p Results AP presence increased reactive species (RS) generation only in the heart, while the other analyzed organs did not have this parameter modified. Heart and pancreas had a decreased endogenous antioxidant system (catalase activity and vitamin C levels), liver and kidney had an increased one. AP increased NKA activity in the heart, liver, and pancreas, but not in the kidney. Conclusion The modulation of both endogenous antioxidant defense system and NKA activity in vital organs suggested that alterations in the antioxidant status and cellular electrochemical gradient may be involved in the AP pathophysiology.
Databáze: OpenAIRE
Externí odkaz: