Stable isosteres of neurotensin c-terminal pentapeptides derived by modification of the amide function
| Autor: | Alexander L. Johnson, William K. Schmidt, S. William Tam, Thomas E. Christos, Argyrios G. Arvanitis, Richard S. Pottorf, Gary A. Cain |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Double bond Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Combinatorial chemistry chemistry.chemical_compound chemistry In vivo Amide Drug Discovery Molecular Medicine Peptide bond Molecular Biology Function (biology) Neurotensin |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:1035-1040 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80282-6 |
| Popis: | A series of amide bond modified neurotensin c-terminal pentapeptides has been prepared and tested for their in vivo analgesic properties. Reduced amide function and trans double bond isosteres did show analgesic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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