Adoptive infusion of tolerance dendritic cells prolongs survival of small intestine allografts in rats: systematic review and meta-analysis
| Autor: | Yanni Zhou, Yingjia Guo, Mengjuan Xia, Youping Li, Yang Tong, Guixiang Sun, Li Feng, Juan Shan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Drug
medicine.medical_specialty business.industry Health Policy medicine.medical_treatment media_common.quotation_subject General Medicine Gastroenterology Small intestine Immune tolerance Transplantation medicine.anatomical_structure Cytokine Internal medicine Meta-analysis Allograft survival Immunology medicine Cytotoxic T cell business media_common |
| Zdroj: | Journal of Evidence-Based Medicine. 6:185-196 |
| ISSN: | 1756-5391 |
| DOI: | 10.1111/jebm.12050 |
| Popis: | Background Postoperative infections and rejection are the main limiting factors of small intestine allograft survival. In this study, we performed a systematic review and meta-analysis to review rat small intestine allograft survival following infusion of tolerance dendritic cells (Tol-DCs) induced by different methods. Methods Relevant publications were searched from PubMed database and EMbase database. Meta-analysis was performed using RevMan 5.0 software. We chose allograft survival, mixed leukocyte reaction, Th1/Th2 differentiation, Treg induction, and cytotoxic T lymphocyte activity as the outcomes by which to examine possible mechanisms that promote survival. Results Eleven suitable articles were identified and assessed. Tol-DCs induced by four methods all prolonged allograft survival. The difference in survival time between the Tol-DC group and the control group was indicated by SMD as follows: drug intervention (SMD = 3.02, 95% CI 1.16 to 4.88, P = 0.001), gene modification (SMD = 2.43, 95% CI 1.77 to 3.10, P < 0.00001), imDC (SMD = 1.76, 95% CI 0.90 to 2.62, P < 0.0001), cytokine induction (SMD = 1.68, 95% CI 0.40 to 2.96, P = 0.01). Tol-DCs were also synergistic with immunosuppressive drugs or costimulation inhibitors, but no immune tolerance was observed. A single-dose intravenous injection of 5×106 to 6×106 Tol-DCs showed the highest allograft survival. Possible mechanisms included donor-specific T-cell hyporesponsiveness and Th2 differentiation. Conclusions Our results demonstrated that Tol-DCs induced by four methods prolong rat small intestine allograft survival. Intravenous infusion of 5×106 to 6×106 Tol-DCs was the optimum dose in rat small intestine transplantation. Immunosuppressive or costimulatory blockade was synergistic with Tol-DC on graft survival. Additional high-quality studies with larger sample sizes are needed to better investigate small intestinal graft longer term survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text