Ionic liquid supported 4-HO-Pro-Val derived organocatalysts for asymmetric aldol reactions in the presence of water

Autor:	Galina M. Zhdankina, Alexander S. Kucherenko, Galina V. Kryshtal, Heena Inani, Easwar Srinivasan, Vasily V. Perepelkin, Sergei G. Zlotin
Rok vydání:	2016
Předmět:	Aqueous solution 010405 organic chemistry General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis Ion chemistry.chemical_compound Aldol reaction chemistry Yield (chemistry) Ionic liquid Organic chemistry Selectivity Derivative (chemistry)
Zdroj:	Mendeleev Communications. 26:388-390
ISSN:	0959-9436
Popis:	Novel (4 R )-HO-(2 S )-Pro-( S )-Val derivative tagged to 1-methylimidazolium cation and P F 6 ¯ anion efficiently catalyzes asymmetric aldol reactions of cyclic ketones with aromatic aldehydes in aqueous environment to afford the corresponding aldols in high yield with moderate to high anti -diastereo- ( dr up to 99: 1) and enantioselectivity (up to 98% ee ). The catalyst was recycled 9 times in the same reaction without any decrease in selectivity values.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8847075c22414163766dcc7d24d65120 https://doi.org/10.1016/j.mencom.2016.09.007 Zobrazit plný text záznamu Full Text from ScienceDirect