A Carcinogenicity Assay of Mirex in Charles River CD Rats2

Autor:	Norbert P. Page, Robert A. Squire, Elizabeth K. Weisburger, Robert L. Cypher, Borge M. Ulland
Rok vydání:	1977
Předmět:	Cancer Research Leukemia Pathology medicine.medical_specialty Oncology Hepatocellular carcinoma Male rats Carcinoma medicine Experimental pathology Biology medicine.disease Carcinogen
Zdroj:	JNCI: Journal of the National Cancer Institute. 58:133-140
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/58.1.133
Popis:	The long-term administration of 50 and 100 ppm of Mirex in the diets of male and female Charles River CD rats was associated with a spectrum of liver lesions, from foci or areas of cellular alteration and neoplastic nodules to hepatocellular carcinoma. Statistically significant numbers of neoplastic nodules were observed in the livers of male rats receiving the high dose. Neoplastic nodules and hepatocellular carcinomas were not observed in control rats.
Databáze:	OpenAIRE
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