Effects of alcohol before, during and after acute paraquat poisoning in rats

Autor:	Dan Du, Hongguang Gao, Yu Cao
Rok vydání:	2014
Předmět:	biology Cmax Alcohol Lung injury Pharmacology Toxicology medicine.disease_cause PARAQUAT POISONING chemistry.chemical_compound chemistry Paraquat Myeloperoxidase Anesthesia medicine biology.protein Hydroxyl radical Oxidative stress
Zdroj:	Toxin Reviews. 33:221-226
ISSN:	1556-9551 1556-9543
DOI:	10.3109/15569543.2014.954135
Popis:	This study aimed to explore the effects of alcohol on paraquat dichloride (PQ) poisoning. Compared to PQ administration alone, alcohol gavage intervention before PQ administration could delay the peak time of plasma Cmax. Myeloperoxidase (MPO) levels were correlated with the level of hydroxyl radical inhibiting ability. The alcohol gavage intervention led to aggravated acute lung injury by improving the inflammatory reaction and reactive oxygen generation. There was a positive correlation between oxidative stress and inflammatory reaction after acute PQ administration. Alcohol intake in combination with PQ poisoning can increase MPO levels, reduce OH− and aggravate lung tissue damage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::883516dc6f9729b9f570f3d405807f98 https://doi.org/10.3109/15569543.2014.954135 Zobrazit plný text záznamu