Synthesis of tritium labelled sparsomycin
| Autor: | Leon A. G. M. van den Broek, Kitty C. M. W. Willemsen, Harry C. J. Ottenheijm, Frans M. Kaspersen, Irene H. G. Schlachter |
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| Rok vydání: | 1989 |
| Předmět: |
Protein synthesis inhibitor
Organic Chemistry chemistry.chemical_element Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry High specific activity Drug Discovery Sparsomycin Cysteine methyl ester Radiology Nuclear Medicine and imaging Lithium Tritium Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 27:583-588 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580270512 |
| Popis: | The synthesis is described of tritiated sparsomycin (5), a broad-spectrum antitumor antibiotic, with high specific activity (31.4 Ci/mmol, 1.16 TBq/mmol). The radiolabel was introduced by reduction of the cysteine methyl ester 1 with lithium borotritide. 3H NMR analysis of the final product showed the concomitant formation of the mono- and ditritiated compound in a ratio of 2:1. |
| Databáze: | OpenAIRE |
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