Autor: |
Carmine Coppola, Loreta A. Kondili, Laura Staiano, Simona Cammarota, Anna Citarella, Mirko Pio Aloisio, Angelo Annunziata, Francesca Futura Bernardi, Aldo D’Avino, Michele D’Orazio, Marianna Fogliasecca, Mario Fusco, Federica Pisano, Adriano Vercellone, Elvira Bianco, Ugo Trama |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Pathogens. 12:195 |
ISSN: |
2076-0817 |
Popis: |
This study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV-infected subjects (2018–2022). Prospective analysis: all subjects admitted to a division of the LHU largest hospital (2021–2022) were tested for HCV, with linkage of active-infected patients to care. Overall, 49287 subjects were HCV-Ab tested: 1071 (2.2%) resulted positive without information for an HCV RNA test and 230 (0.5%) had an active infection not yet cured. Among 856 admitted subjects, 54 (6.3%) were HCV-Ab+ and 27 (3.0%) HCV RNA+. Of HCV-infected patients, 22.2% had advanced liver disease, highlighting the need for earlier diagnosis; 27.7% were unaware of HCV infection; and 20.4% were previously aware but never referred to a clinical center. Of these, 26% died and 74% received treatment. Our study emphasizes the value of an active HCV hospital case-finding program to enhance diagnosis in patients with several comorbidities and to easily link them to care. Our data strongly suggest extending this program to all hospital wards/access as a standard of care, particularly in highly endemic areas, to help HCV disease control and take steps in achieving the elimination goals. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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