A Mild and Efficient Method for Tetrahydropyranylation/Depyranylation of Alcohols and Phenols Under Neutral Conditions

Autor:	K. Rama Rao, L. Rajender Reddy, M. Arjun Reddy, N. Bhanumathi
Rok vydání:	2000
Předmět:	Reaction conditions Solvent chemistry.chemical_compound chemistry Acid sensitive Lithium bromide Organic Chemistry Organic chemistry Methanol Phenols Dichloromethane
Zdroj:	Synthetic Communications. 30:4323-4328
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397910008087055
Popis:	Alcohols and phenols are tetrahydropyranylated rapidly in high yields in the presence of lithium bromide and dichloromethane at room temperature. Deprotection of these THP ethers can also be effected readily by mere change of the solvent to methanol and refluxing with excess lithium bromide. Due to neutral reaction conditions employed, the method is also compatible with compounds having acid sensitive functional groups.
Databáze:	OpenAIRE
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