ChemInform Abstract: A Multicomponent Access to 1,3-Thiazine-6-phenylimino-5-carboxylates

Autor:	Adam McCluskey, Trieu N. Trinh
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Acetic anhydride chemistry Thiazine Yield (chemistry) Moiety General Medicine Medicinal chemistry Benzoic anhydride
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201646187
Popis:	The multicomponent reaction of ethyl 3-aminocrotonate ( 1 ), substituted phenylisothiocyanates ( 2a – i ) and acetic anhydride ( 7 ), afforded facile access to a series of substituted 1,3-thiazine-6-phenylimino-5-carboxylates under mild conditions in 15–65% yields. Limited tolerance for modification of the anhydride moiety was noted with a significant reduction in yield for propionic and trifluoroacetic anhydrides. The use of benzoic anhydride favoured a two-component coupling product.
Databáze:	OpenAIRE
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