Enediynes as Antitumor Compounds: Synthesis of Tetrahydropyridine Derivatives

Autor:	Miguel F. Braña, M. Moran, and María Jesús Pérez de Vega, I. Pita‐Romero
Rok vydání:	1996
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Quinoline Intercalation (chemistry) Enediyne Moiety Fluorene Pharmacophore Ring (chemistry) Two-dimensional nuclear magnetic resonance spectroscopy Combinatorial chemistry
Zdroj:	The Journal of Organic Chemistry. 61:1369-1374
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo951188l
Popis:	Enediyne anticancer antibiotics are a rapidly emerging class of compounds derived from natural sources. Many synthetic approaches for the construction of simpler compounds containing this pharmacophore have recently been published. Most of these approaches use the quinoline ring as the heterocyclic moiety . In this paper, we describe a synthetic route for the preparation of enediyne systems 14 and 15, which include in their structure a tetrahydropyridine ring and are related to dynemicin A. Their stereochemistries were determined using NOESY and COSY-NMR. Finally, compounds derived from linkage to intercalating carriers, such as a fluorene ring to enediyne 15 or a naphthalimide ring to acyclic enediyne 6, were prepared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::882eed060c68f0d8d392e8c2db32b4cb https://doi.org/10.1021/jo951188l Zobrazit plný text záznamu