Quantitative study of chimpanzee and gorilla counterparts of the human D antigen
| Autor: | J. Ruffie, F. Roubinet, Antoine Blancher, W. W. Socha |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
General Veterinary
biology medicine.diagnostic_test medicine.drug_class hemic and immune systems Gorilla Immunofluorescence Monoclonal antibody Virology Molecular biology Epitope Red blood cell medicine.anatomical_structure Antigen biology.animal Monoclonal biology.protein medicine Animal Science and Zoology Antibody circulatory and respiratory physiology |
| Zdroj: | Journal of Medical Primatology. 22:29-35 |
| ISSN: | 1600-0684 0047-2565 |
| Popis: | The reactivities of three human anti-D monoclonal antibodies (mAbs) with human, chimpanzee, and gorilla red blood cells (RBCs) were compared by quantitative radioimmunology and indirect immunofluorescence methods. The number of antigenic sites varies widely in gorillas (from 48,000-283,000), while in chimpanzees this number is very close to that observed in human R1R2 RBCs. The affinity of the anti-D antibodies was slightly lower with ape RBCs than with D-positive human RBCs. In chimpanzee, the D-like epitopes recognition is enhanced by papain while the gorilla D-like epitopes are destroyed by enzyme treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|