Gold(I ) complexes of 1-diphenylarsino-2-diphenylphosphinoethane (dadpe): solution studies, X-ray crystal structures, and cytotoxicity of [(AuCl)2dadpe]·0.5dma (dma = dimethylacetamide) and [Au(dadpe)2]Cl·2H2O
| Autor: | Peter J. Sadler, Reiko Kuroda, Orla M. Ni Dhubhghaill |
|---|---|
| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | J. Chem. Soc., Dalton Trans.. :2913-2921 |
| ISSN: | 1364-5447 0300-9246 |
| DOI: | 10.1039/dt9900002913 |
| Popis: | The complexes [(AuCl)2dadpe](1) and [Au(dadpe)2]Cl (2) where dadpe is Ph2PCH2CH2AsPh2 have been prepared and characterized by n.m.r. spectroscopy (31P-{1H}, 1H, and 13C-{1H}) and by X-ray crystallography. 31P-{1H} N.m.r. spectroscopy shows that complex (1) is converted into (2) on titration with dadpe in CDCl3 at a Au: dadpe ratio of 1:2. At higher ratios there is exchange between complex (2) and the excess of ligand. Such rapid ligand exchange is also indicated by the 1H n.m.r. data. Crystals of (1) are monoclinic, space group Cc with a= 19.385(3), b= 11.011(2), c= 27.260(1)A, β= 96.40(1)°, and Z= 8. The ligand co-ordinates two AuCl chains with intermolecular Au ⋯ Au contact of 3.21 A. The P and As atoms are disordered and there appears to be conformational flexibility about the ethane bridge. Crystals of (2) are monoclinic, space group P21/n, a= 10.192(1), b= 21.797(7), c= 21.683(10)A, β= 94.14(3)°, and Z= 4 and contain bis chelated AuI in a distorted-tetrahedral environment; again the P and As atoms are disordered. Complexes (1) and (2) are significantly more toxic towards L1210, WS, and V.79 cells in vitro than is the free ligand, dadpe, and are comparable to [Au(dppe)2]Cl in their toxicity towards WS and V.79 cell lines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|