daf-12encodes a nuclear receptor that regulates the dauer diapause and developmental age inC. elegans

Autor:	Wen-Hui Yeh, Donald L. Riddle, Danilo Tait, Edward M. Hedgecock, Adam Antebi
Rok vydání:	2000
Předmět:	Genetics Regulation of gene expression Mutation biology Dauer larva biology.organism_classification medicine.disease_cause Dauer entry Nuclear receptor medicine Receptor Gene Caenorhabditis elegans Developmental Biology
Zdroj:	Genes & Development. 14:1512-1527
ISSN:	1549-5477 0890-9369
DOI:	10.1101/gad.14.12.1512
Popis:	Thedaf-12gene acts at the convergence of pathways regulating larval diapause, developmental age, and adult longevity inCaenorhabditis elegans. It encodes a nuclear receptor most closely related to twoC. elegansreceptors, NHR-8 and NHR-48,DrosophilaDHR96, and vertebrate vitamin D and pregnane-X receptors.daf-12has three predicted protein isoforms, two of which contain DNA- and ligand-binding domains, and one of which contains the ligand-binding domain only. Mutations cluster in DNA- and ligand-binding domains, but correspond to distinct phenotypic classes. DAF-12 is expressed widely in target tissues from embryo to adult, but is upregulated during midlarval stages. In the adult, expression persists in nervous system and somatic gonad, two tissues that regulate adult longevity. We propose that DAF-12 integrates hormonal signals in cellular targets to coordinate major life history traits.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8819637ef788b2229a86760587f528d6 https://doi.org/10.1101/gad.14.12.1512 Zobrazit plný text záznamu