Highly enantioselective desymmetrizations of meso-anhydrides

Autor:	Ingo Schiffers, Ellen Schmitt, Carsten Bolm
Rok vydání:	2010
Předmět:	Cyclic compound Cyclohexane Chemistry Organic Chemistry Enantioselective synthesis Alcohol Biochemistry Catalysis chemistry.chemical_compound Benzyl mercaptan Nucleophile Drug Discovery Organic chemistry Enantiomeric excess
Zdroj:	Tetrahedron. 66:6349-6357
ISSN:	0040-4020
DOI:	10.1016/j.tet.2010.04.121
Popis:	Readily available, low molecular cyclohexane-based organocatalysts promote highly enantioselective desymmetrizations of cyclic meso-anhydrides applying alcohols and benzyl mercaptan as nucleophiles. Both succinic and glutaric anhydrides furnished the corresponding products with up to 96% ee in mostly quantitative yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8817a207712b2917c9ebbcf9ec7aeba0 https://doi.org/10.1016/j.tet.2010.04.121 Zobrazit plný text záznamu Full Text from ScienceDirect