Synthesis and Characterization of Dendrotoxin: A Potent Potassium Channel Inhibitor
| Autor: | M. E. Byrnes, V.M. Mahnir, W.R. Kem, M. W. Pennington |
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| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Protein & Peptide Letters. 1:239-245 |
| ISSN: | 0929-8665 |
| Popis: | Dendrotoxin, a 59 residue peptide toxin was synthesized using an Fmoc-tBu strategy and folded to the biologically active form . Synthetic dendrotoxin co-eluted with the natural toxin by RP-HPLC, and inhibited [125]-dendrotoxin I binding to rat brain synaptosomes with an IC50=20 nM which was comparable to the natural toxin . |
| Databáze: | OpenAIRE |
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