Synthesis and biological properties of certain chloroorganophosphorus compounds

Autor:	R. A. Asadov, M. N. Nazypov, S. D. Anisin, K. V. Nikonorov, É. A. Gurylev, L. G. Urazaeva
Rok vydání:	1969
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Chemical structure Biological property Brain cortex Chloral Organic chemistry Biological activity General Chemistry Aldehyde Adduct
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 18:2090-2096
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf00906626
Popis:	1. The reaction of 1-hydroxy-2,2,2-trichloroethylphosphonous acid with aldehydes and ketones yields the corresponding adducts. These adducts on reaction with anhydrides of carboxylic acids give acyl derivatives. 2. The biological activity of the condensation products of hypohosphorous acid with chloral and aldehydes and ketones has been studied; an assumption is expressed concerning the presence of an adrenolytic action and effect of these compounds on the metabolic processes of myocardium; a study of the effect of organophosphorus derivatives of chloral on the central nervous system led to a suggestion concerning the deprimenting action of the compounds on brain cortex. 3. A study of the insecticidal properties of the compounds synthesized indicated that they are weak insecticides. 4. All of the compounds synthesized show fungistatic activity. 5. A correlation is traced between the chemical structure of the compounds and their biological action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::881218dd1d7e4a620fb705d5217cb9e4 https://doi.org/10.1007/bf00906626 Zobrazit plný text záznamu Full text from SpringerLink