Clinical applications of molecular profiling in colorectal cancer: Review of the literature

Autor:	Elrasheid A. H. Kheirelseid, Nicola Miller, Michael J. Kerin
Rok vydání:	2013
Předmět:	Colorectal cancer business.industry Disease medicine.disease Bioinformatics medicine.disease_cause Psychiatry and Mental health medicine Curative surgery Profiling (information science) Differential expression Colorectal cancer genetics Carcinogenesis business
Zdroj:	American Journal of Molecular Biology. :131-138
ISSN:	2161-6663 2161-6620
DOI:	10.4236/ajmb.2013.32017
Popis:	Despite the developments in the diagnostic and management strategies, a considerable number of colorectal cancer (CRC) patients present with disease recurrence after curative surgery. Moreover; there are no reliable indicators to determine the prognosis and response of CRC patients to therapy. By harnessing recent technological advances in molecular profiling techniques, it is anticipated that greater insight to the various combinations of genetic events or alternative pathways underlying carcinogenesis will be gained. By carrying out literature search, we were able to identify a comprehensive list of genes with high differential expression patterns in colorectal cancer that could serve as molecular markers to complement existing histopathological factors in diagnosis, follow up and therapeutic strategies for individualized care of patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8811588b085fe93b6ae4360223d121ca https://doi.org/10.4236/ajmb.2013.32017 Zobrazit plný text záznamu