Efficient Synthesis of11C-Acrylesters,11C-Acrylamides and Their Application in Michael Addition Reactions for PET Tracer Development

Autor:	Ulrike Filp, Alex J. Poot, Carlotta Taddei, Albert D. Windhorst, Anna Pees, Aleksandra Pekošak, Antony D. Gee
Rok vydání:	2017
Předmět:	Schiff base 010405 organic chemistry Organic Chemistry Synthon 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Michael reaction Organic chemistry Physical and Theoretical Chemistry Pet tracer Carbonylation
Zdroj:	European Journal of Organic Chemistry. 2017:5154-5162
ISSN:	1434-193X
Popis:	Here we present a new Michael addition reaction utilizing carbon-11 labeled acrylic esters and amides. Subsequently, reactions of these synthons with commercially available Schiff base precursors are performed to produce [11C]glutamate and [11C]glutamine. This methodology is especially useful for the development of positron emission tomography (PET) imaging agents as it offers a new array of potential carbon-11 labeled compounds with this original 11C–C bond forming strategy.
Databáze:	OpenAIRE
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