An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

Autor:	Thomas R. Verhoeven, Paul J. Reider, Robert D. Larsen, Lushi Tan, Cheng-yi Chen
Rok vydání:	1998
Předmět:	Trifluoromethylation Stereochemistry Chemistry Organic Chemistry Drug Discovery Enantioselective synthesis COX-2 inhibitor Sharpless asymmetric dihydroxylation Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 39:3961-3964
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)00735-7
Popis:	An efficient enantioselective synthesis of L-784,512 featuring a Horner-Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87ff68e71afb4087010d418cb727d74d https://doi.org/10.1016/s0040-4039(98)00735-7 Zobrazit plný text záznamu Full Text from ScienceDirect