Synthetic Studies towards Leiodermatolide: Rapid Stereoselective Syntheses of Key Fragments

Autor:	Vaidotas Navickas, Christian Rink, Martin E. Maier
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Intramolecular reaction chemistry Stereochemistry Organocatalysis Intramolecular force Organic Chemistry Fráter–Seebach alkylation Stereoselectivity Reformatsky reaction Aldehyde Chemical synthesis
Zdroj:	Synlett. 2011:191-194
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0030-1259286
Popis:	The synthesis of three key fragments of the novel 16-membered macrolide leiodermatolide is described. The stereotetrad-containing building block was prepared via a Marshall-Tamaru reaction on an aldehyde obtained by organocatalysis. For a second building block, a Marshall―Tamaru reaction was used as well. The side-chain fragment containing a hydroxy δ-lactone could be obtained by intramolecular Reformatsky reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87fc6d32381c70d08c0c9efabab6e7b6 https://doi.org/10.1055/s-0030-1259286 Zobrazit plný text záznamu