Embryonal tumor with multilayered rosettes, C19MC-altered with sarcomatous differentiation: histopathologic and molecular characterization of one case

Autor:	Christelle Dufour, Michel Zerah, Albane Gareton, Volodia Dangouloff-Ros, Arnault Tauziède-Espariat, Nathalie Boddaert, Emmanuèle Lechapt, Pascale Varlet
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty General Medicine In situ hybridization Biology Sarcomatous Component Pathology and Forensic Medicine Embryonal tumors medicine.anatomical_structure Neurology Divergent Differentiation Neuropil medicine Neurology (clinical)
Zdroj:	Clinical Neuropathology. 40:11-16
ISSN:	0722-5091
Popis:	Embryonal tumor with multilayered rosettes, constitutes an aggressive and rare pediatric embryonal tumor of the central nervous system characterized by alterations of the C19MC locus at 19q13.12. Embryonal tumors with multilayered rosettes (ETMRs) span a broad histopathological spectrum with primitive neural features and abundant neuropil. Before the molecular definition of this entity, exceptional cases with heterologous differentiation have been evidenced in the literature. Herein, we report the first case of an ETMR featuring a sarcomatous component with proven C19MC alteration in both components by an in situ hybridization analysis. This data supports the hypothesis of a divergent differentiation of tumoral cells in this case.
Databáze:	OpenAIRE
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