Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: A matched pair analysis
| Autor: | Munita Bal, Komal Lamba, Sudhir Nair, Arjun Singh, Akshat Malik, Atanu Bhattacharjee, Swapnil Rane, Pankaj Chaturvedi, Hisham Mehanna |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Poor prognosis Matched Pair Analysis business.industry medicine.medical_treatment Hazard ratio Cancer Soft tissue Neck dissection medicine.disease Gastroenterology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Lymphatic system Otorhinolaryngology 030220 oncology & carcinogenesis Internal medicine medicine Adjuvant therapy business |
| Zdroj: | Head & Neck. 42:1783-1790 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.26103 |
| Popis: | Background Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes. Methods The records of 4812 treatment naive oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated. Results STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value .0073) and DFS (HR-2.5; P-value .0002) with and without ENE [HR-1.96 and 3.7, respectively]. Conclusion Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes. |
| Databáze: | OpenAIRE |
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