New dihydrostilbenes from Macaranga heynei I.M. Johnson, biological activities and structure-activity relationship

Autor:	Mohd Izwan Mohamad Yusof, Zetty Zulikha Hafiz, Aisyah Salihah Kamarozaman, Mohd Ilham Adenan, Norizan Ahmat, Nik Fatini Nik Azmin, Jalifah Latip, Siti Nursyahirah Mohd Isa
Rok vydání:	2019
Předmět:	chemistry.chemical_classification biology 010405 organic chemistry Chemistry Stereochemistry Chemical structure Euphorbiaceae Plant Science biology.organism_classification 01 natural sciences Biochemistry Acetylcholinesterase 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Enzyme Structure–activity relationship Medicinal plants Agronomy and Crop Science Chemical composition Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology
Zdroj:	Phytochemistry Letters. 30:174-180
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2019.02.002
Popis:	Four new dihydrostilbenes, malayheyneiins A–D (1–4) along with three known analogues, laevifolins A–B (5–6) and macarubiginosin C (7) were isolated from the leaves of Macaranga heynei. The structures of the compounds were elucidated using 1D and 2D NMR, UV, IR, MS as well as comparison with literature data. Compounds 2, 3 and 7 exhibited significant acetylcholinesterase inhibitory (AChEI) activity with IC50 of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87ea7943fe6d8de95a8aeddc5fd0d216 https://doi.org/10.1016/j.phytol.2019.02.002 Zobrazit plný text záznamu Full Text from ScienceDirect