Structure of clovanemagnolol, a novel neurotrophic sesquiterpene-neolignan from magnolia obovata
| Autor: | Mitsuaki Kodama, Takashi Hasegawa, Hiroshi Okazaki, Yoshiyasu Fukuyama, Yukio Otoshi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
biology
Stereochemistry Organic Chemistry Sesquiterpene biology.organism_classification Biochemistry Magnolol chemistry.chemical_compound chemistry Clovanemagnolol Cell culture Biomimetic synthesis visual_art Drug Discovery visual_art.visual_art_medium biology.protein Bark Magnolia obovata Neurotrophin |
| Zdroj: | Tetrahedron Letters. 31:4477-4480 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(00)97653-6 |
| Popis: | The structure of novel sesquiterpene-neolignan, clovanemagnolol (1), isolated from the bark of Magnolia obovata has been elucidated on the basis of the extensive 2D-NMR analyses and finally substantiated by one-step biomimetic synthesis from caryophyllene oxide and magnolol. Clovanemagnolol has exhibited neurotrophic activity at 10 −7 M on neuronal cell culture system of fetal rat cerebral hemisphere. |
| Databáze: | OpenAIRE |
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