Organ culture mimics the effects of hypoxia on membrane potential, K+ channels and vessel tone in pulmonary artery

Autor:	Sarah L. Etheridge, Joy Reid, Alison M. Gurney, Boris Manoury
Rok vydání:	2009
Předmět:	Pharmacology Membrane potential Pathology medicine.medical_specialty Endothelium Hypoxia (medical) Biology Organ culture medicine.anatomical_structure medicine.artery Pulmonary artery Circulatory system medicine Myocyte medicine.symptom Blood vessel
Zdroj:	British Journal of Pharmacology. 158:848-861
ISSN:	0007-1188
DOI:	10.1111/j.1476-5381.2009.00353.x
Popis:	Background and purpose: Blood vessel culture is gaining interest for use with transfection-based techniques, but alters the contractile properties of the vessels. The present study tested the effects of culture on the intrinsic tone of rat pulmonary arteries (PAs) and examined the function and expression of K+ channels regulating the resting membrane potential (Em) and tone of pulmonary artery smooth muscle cells (PASMCs).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87dfb03efaf2a5ea4eb6290042ea369f https://doi.org/10.1111/j.1476-5381.2009.00353.x Zobrazit plný text záznamu Plný text ve formátu PDF