Defective gallbladder emptying and cholecystokinin release in celiac disease
| Autor: | Vs Chadwick, A.C. Selden, M.L. Fitzpatrick, P.N. Maton |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Meal
medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Gastroenterology nutritional and metabolic diseases Radioimmunoassay digestive system diseases Endocrinology Internal medicine Biopsy medicine Gluten free In patient Villous atrophy Gallbladder Emptying business Cholecystokinin |
| Zdroj: | Gastroenterology. 88:391-396 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/0016-5085(85)90497-4 |
| Popis: | Normal volunteers (n = 6), patients with untreated celiac disease and subtotal villous atrophy (n = 6), patients with nonresponsive celiac disease (n = 2), and patients with celiac disease on a gluten-free diet with a virtually normal biopsy specimen (n = 6) drank a liquid fat meal after an overnight fast. Gallbladder emptying was monitored by using 99m Tc-eHIDA, and blood samples were taken for cholecystokinin estimation by radioimmunoassay after high-performance liquid chromatography. The half-times of gallbladder emptying were 20.4 ± 2.9 min (mean ± SEM) for normals and 22.1 ± 2.8 min in treated patients with celiac disease (NS). In patients with untreated celiac disease half-times were 154.3 ± 10.3 min (p −1 · 30 min −1 in normals and treated patients with celiac disease (NS). In untreated patients with celiac disease values were 16 ± 9 pmol · L −1 · 30 min −1 (p −1 · 30 min −1 . In 2 patients studied before and during gluten-free diet half-times for gallbladder emptying changed from 168.9 and 302.4 min to 20.1 and 23.4 min, and cholecystokinin responses changed from 0 and 45 to 623 and 298 pmol · L −1 · 30 min −1 . Cholecystokinin immunoreactivity cochromatographing with cholecystokininoctapeptide was responsible for 50%–60% of circulating cholecystokinin in normals and in treated patients but the small amount of cholecystokinin that was released in untreated patients with celiac disease cochromatographed with cholecystokinin-3339. We conclude that there is a reversible defect of gallbladder emptying and cholecystokinin release in celiac disease. |
| Databáze: | OpenAIRE |
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