| Autor: |
Kenneth W. McKerns, H.H. Bird, B.S. Coulomb, E. Kaleita, E.C. De Renzo |
| Rok vydání: |
1960 |
| Předmět: |
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| Zdroj: |
Biochemical Pharmacology. 3:305-315 |
| ISSN: |
0006-2952 |
| DOI: |
10.1016/0006-2952(60)90096-4 |
| Popis: |
Hypoglycin (2-amino-methylenecyclopropanepropionic acid), isolated from the seeds of Blighia sapida, induced a marked hypoglycemia when administered to rats. Little direct effect of this compound was observed on glucose metabolism, either on glucose oxidation to respiratory CO2 or on conversion of glucose to liver lipid or muscle glycogen. Synthesis of glycogen from glucose in diaphragm muscle was inhibited by hypoglycin without altering glucose uptake. The major effects of hypoglycin were those concerned with fatty acid metabolism. The administration of hypoglycin to rats caused an increase in the level of non-esterified fatty acids in the serum, an increase in the total lipids of the liver and a significant inhibition in the conversion of butyrate or stoarate to respiratory CO2. Liver mitochondria isolated from hypoglycin-treated rats showed an impaired ability to form high energy phosphate bonds associated with the oxidation of pyruvate and malate. Hypoglycin had no effect on adrenal cortical output. Since hypoglycin lowered blood glucose level only after 3 or 4 hr, the active compound may be a metabolite or the effects on blood sugar may be secondary to some primary metabolic block. Methylenecyclopropanepyruvic acid and methylenecyclo-propaneacetic acid, both likely metabolites, do produce hypoglycemia. The possibility that such intermediates interfere with the oxidation of fatty acid substrates is briefly discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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