Diversity of ACTH (cAMP)‐dependent transcription of bovine steroid hydroxylase genes

Autor:	Michael R. Waterman, Larry J. Bischof
Rok vydání:	1997
Předmět:	medicine.medical_treatment Biology Biochemistry Steroid hormone chemistry.chemical_compound chemistry Transcription (biology) Genetics medicine Steroid hydroxylase Transcriptional regulation Signal transduction Molecular Biology Gene Transcription factor Biotechnology Steroid Hydroxylases
Zdroj:	The FASEB Journal. 11:419-427
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fasebj.11.6.9194522
Popis:	An essential role of ACTH is to assure that optimal steroidogenic capacity is maintained in the adrenal cortex throughout life. This is achieved by maintaining transcriptional pressure on the genes encoding the adrenocortical steroid hydroxylases via the second messenger, cAMP. Even though these genes respond coordinately to cAMP, it has been surprising to discover that each gene uses its own unique cAMP response system during this coordinate response. Thus, different cis elements and sets of transcription factors control the cAMP responsiveness of each different steroid hydroxylase gene. Although the physiological basis of this diversity in biochemical mechanisms of transcriptional regulation is not apparent, a portion of this signaling pathway is common to all of these genes. In particular, the action of cAMP-dependent protein kinase and an as yet uncharacterized cycloheximide-sensitive step are necessary for ACTH-mediated transcription of each gene. Biochemical characterization of these common steps in...
Databáze:	OpenAIRE
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