Diterpenoids and Flavonoids from Andrographis paniculata
| Autor: | Tran Hong Quang, Nguyen Hoai Nam, Pham Thi Cham, Nguyen Xuan Cuong, Chau Van Minh, Tran Thu Huong, Nguyen Thi Thuy My, Tran Thi Hong Hanh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chalcone
biology 010405 organic chemistry Stereochemistry Andrographolide General Chemistry General Medicine 010402 general chemistry biology.organism_classification 01 natural sciences Terpenoid 0104 chemical sciences Nitric oxide chemistry.chemical_compound chemistry Glucoside Drug Discovery Cytotoxicity IC50 Andrographis paniculata |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 68:96-99 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Chemical investigation of the aerial parts of Andrographis paniculata resulted in isolation of nine compounds, including a new ent-labdane diterpenoid, andrographic acid methyl ester (1), a new chalcone glucoside, pashanone glucoside (5), and seven known metabolites, andrograpanin (2), andrographolide (3), andropanolide (4), andrographidine A (6), andrographidine F (7), 6-epi-8-O-acetyl-harpagide (8), and curvifloruside F (9). Their chemical structures were elucidated based on comprehensive analyses of the spectroscopic data, including NMR and MS. Among the isolated compounds, andropanolide exerted cytotoxicity toward LNCaP, HepG2, KB, MCF7, and SK-Mel2 carcinoma cells, with IC50 values ranging from 31.8 to 45.9 µM. In addition, andropanolide significantly inhibited the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with an IC50 value of 13.4 µM. |
| Databáze: | OpenAIRE |
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