Silver-catalysed hydroamination: synthesis of functionalised pyrroles

Autor:	David Gravestock, Martin C. Dovey, Ross S. Robinson
Rok vydání:	2004
Předmět:	Chemistry fungi Organic Chemistry food and beverages Biochemistry Silver nitrate chemistry.chemical_compound Microwave heating Intramolecular force Drug Discovery Polymer chemistry Organic chemistry Propargyl bromide Hydroamination Amination
Zdroj:	Tetrahedron Letters. 45:6787-6789
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2004.07.019
Popis:	It has been shown that functionalised pyrroles can be efficiently prepared using a two-step sequence. This sequence involves the propargylation of secondary enaminones using n-BuLi and propargyl bromide, followed by intramolecular hydroamination catalysed by silver nitrate. The hydroamination can be carried out at room temperature (overnight) or in a domestic microwave oven (60 s).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87bf9cc170a07b958ef96317e131e317 https://doi.org/10.1016/j.tetlet.2004.07.019 Zobrazit plný text záznamu Full Text from ScienceDirect