The Predictive Value and Evolution of N-Terminal Pro-B-Type Natriuretic Peptide Levels Following Transcutaneous Aortic Valve Implantation
| Autor: | Marina Balanika, George Dangas, George Stavridis, Konstantinos Spargias, Antonis Dimopoulos, Gregory Pavlides, Spyros Polymeros, Athanassios Manginas, Anna Smirli, Dennis V. Cokkinos |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Aortic valve
medicine.medical_specialty medicine.drug_class business.industry Predictive value Surgery medicine.anatomical_structure Internal medicine Predictive value of tests Aortic valve surgery medicine Natriuretic peptide Cardiology Radiology Nuclear Medicine and imaging N terminal pro b type natriuretic peptide Cardiology and Cardiovascular Medicine business Chi-squared distribution |
| Zdroj: | Journal of Interventional Cardiology. 24:462-469 |
| ISSN: | 0896-4327 |
| Popis: | Aims: We sought to define the predictive value and evolution of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels following transcutaneous aortic valve implantation (TAVI). Methods and Results: We investigated 91 consecutive patients who underwent TAVI (59 transfemoral [TF], 32 transapical [TA]) in our institution. The balloon-expandable valve was implanted in 75 and the self-expanding in 16 patients. The baseline (within 48 hours prior to procedure), early (24–74 hours), and late (3–12 months) postprocedural NT-proBNP levels were determined. The mortality status of all patients was ascertained as of September 2010. The 30-day and 1.3(mean)-year mortality was 3% and 12% (2%, 9% in the TF and 6%, 19% in the TA group). Increased baseline (χ2= 5.9, P = 0.016) and early (χ2= 4.9, P = 0.028) NT-proBNP levels were predictive of mortality. All decrements of the NT-proBNP levels in the TF patients were significant (baseline 4,984 ± 8,106 vs. early 3,912 ± 6,551 pg/mL, P = 0.016; late 633 ± 606 pg/mL, P = 0.003). In contrast, there was a trend for the early levels to increase in the TA patients (6,423 ± 8,897 vs. 8,100 ± 10,178 pg/mL, P = 0.090), and a significant decline in the late levels as compared to baseline (1,704 ± 3,417 pg/mL, P = 0.005). Conclusion: NT-proBNP levels are predictive of mortality following TAVI. There is a differential early evolution of their levels between the TF and TA patients and a significant decline later in both groups. (J Interven Cardiol 2011;24:462–469) |
| Databáze: | OpenAIRE |
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