2-Carbamoylaziridine (Leakadine): diastereoselective transformations and stereoelectronic effect*

Autor:	I. I. Chervin, Remir G. Kostyanovsky, O. N. Krutius, G. K. Kadorkina
Rok vydání:	2012
Předmět:	Dimethyl acetal chemistry.chemical_compound Chemistry Stereochemistry Dimer Dimethyl formamide Organic Chemistry Stereoelectronic effect Diastereomer Methyl isocyanate Enantiomer Medicinal chemistry Derivative (chemistry)
Zdroj:	Chemistry of Heterocyclic Compounds. 48:869-874
ISSN:	1573-8353 0009-3122
Popis:	Diastereoselective transformations of Leakadine were discovered: dimerization during melting or heating in CHCl3 with the formation of one diastereomer. The obtained dimer reacts with methyl isocyanate under mild conditions with the formation of an N-methylcarbamoyl derivative – also in the form of one diastereomer. In the diastereoselective reaction of Leakadine with dimethyl formamide dimethyl acetal, 2-dimethylamino-1,3-diazabicyclo[3.1.0]hexan-4-one was obtained. The reaction of Leakadine with perfluoroisobutylene was studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87b8be7bebb703ee4c2cbce26c5dc7d1 https://doi.org/10.1007/s10593-012-1068-1 Zobrazit plný text záznamu Plný text ve formátu PDF