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Summary Objective: To examine the potential determinants of plasminogen activator inhibitor (PAI-1), the main regulatory component of the fibrinolytic process, and the relationship of PAI-1 with complications of insulin dependent diabetes mellitus (IDDM). Design: Cross-sectional study. Setting: Diabetes research center. Subjects: Individuals in this study were participants of the Epidemiology of Diabetes Complications study, a 10-year prospective study examining the prevalence, incidence, and interrelationships of the various complications of IDDM. Main Outcome Measures: Major complications of diabetes were assessed by standardized procedures (i.e. retinopathy [fundus photography], neuropathy [based on Diabetes Control and Complications Trial protocol], nephropathy [elevated albumin excretion rate (>200 μg/min)], coronary artery disease [myocardial infarction/angina], lower extremity arterial disease [ankle brachial index of Results: PAI-1 levels were not found to be significantly increased with any specific IDDM complication. Modelling potential correlates in linear regression analyses where PAI-1 was the dependent variable revealed independent associates with body mass index and triglycerides for males and age, fibrinogen, smoking history, and oral contraceptive use for females. Conclusions: The association of PAI-1 and other risk factors is complex with these data indicating an interdependent rather than an independent role for PAI-1 in IDDM complication development. |
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