Increased adrenocortical and adrenomedullary hormonal activity in 12-year-old children born small for gestational age
Autor: | Sirpa Tenhola, Anneli Martikainen, Pirjo Halonen, Raimo Voutilainen, Markku Parviainen, Eero Rahiala |
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Rok vydání: | 2002 |
Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Blood lipids Odds ratio Androgen medicine.disease Confidence interval chemistry.chemical_compound Low birth weight Endocrinology Dehydroepiandrosterone sulfate Epinephrine chemistry Internal medicine Pediatrics Perinatology and Child Health Medicine Small for gestational age medicine.symptom business medicine.drug |
Zdroj: | The Journal of Pediatrics. 141:477-482 |
ISSN: | 0022-3476 |
Popis: | Objectives: To determine whether adrenal hormonal activity is altered in children born small for gestational age (SGA), and whether concentrations of adrenal hormones relate to those of serum lipids or to anthropometric measures. Study design: We studied 55 SGA children and 55 appropriate for gestational age (AGA) children at the age of 12 years in a case-control setting. The concentrations of fasting serum cortisol, dehydroepiandrosterone sulfate (DHEAS), plasma epinephrine (E), and norepinephrine (NE) were analyzed. Results: The SGA children had significantly higher mean concentrations of serum DHEAS (3.53 vs 2.89 μmol/L, P =.009) and plasma E (0.33 vs 0.25 nmol/L, P =.005) than their age- and sex-matched control subjects. The mean serum cortisol and plasma NE concentrations did not differ significantly between the groups. However, the SGA children in the highest quartile for serum cortisol had significantly higher concentrations of plasma E (0.50 vs 0.28 nmol/L, P P =.025) and total cholesterol (5.06 vs 4.42 mmol/L, P =.021) than the SGA children in the lower cortisol quartiles. The factors associating with high levels of plasma E in the SGA children were high level of serum cortisol [odds ratio (OR) = 3.8, 95% confidence interval (95% CI) = 1.5-10], LDL cholesterol (OR = 3.9, 95% CI = 1.3-12), male sex (OR = 8.3, 95% CI = 1.0-68) and low birth weight (OR = 1.4, 95% CI = 1.0-1.8) in multiple logistic regression analysis. Conclusions: Twelve-year-old children born SGA had increased DHEAS and epinephrine levels in circulation. High serum cortisol concentrations are associated with high epinephrine, LDL, and total cholesterol levels. (J Pediatr 2002;141:477-82) |
Databáze: | OpenAIRE |
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